It is analyzed in the Global Burden of Disease Study 2013 that more than a third of the world’s population is suffering from five ailments or more. Complementary and alternative therapies are one way to answer such global health concerns. This paper presents a novel ayurvedic approach developed after 26 years of research on the synergies of different plant-extracts based oil-blends. The approach/concept is based on the Ayurveda Plant Nanocellopathy which is related to nanoscience based system. The salient features of this novel approach are its topical use only treatment with no added chemicals, non-metabolized way with no medicine ingestion. It is a standardized, scientific, safe and proven effective treatment for numerous diseases like polycystic ovarian syndrome, osteoarthritis (an alternative to knee replacement), many lifestyle ailments, infections and allergies and even bio-terror. The natural herbal plant extract oils can be used with conventional treatments as adjuvant or as stand-alone therapy to safeguard human life across the globe.