Can Antioxidant Supplement Prevent Dementia?
Qingcheng Du1* and Xiaojie Zhi2
1School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, P.R.China
2The Second School of Clinical Medicine,Guangdong Medical University,Dongguan, Guangdong, P.R. China
- *Corresponding Author:
- Dr. Qingcheng Du
School of Pharmacy, Guangdong Medical
University, Songshan Lake
No.1, Dongguan, Guangdong 523808
Tel: 7499 677 1864
Received date: February 23, 2018; Accepted date: March 06, 2018; Published date: March 09, 2018
Citation: Du Q, Zhi X (2018) Can Antioxidant
Supplement Prevent Dementia? Insights
Biomed. Vol.3 No.1:5
We did a systematic study about antioxidant supplement in
prevention of dementia. We searched the Web of Science,
EMBASE, PubMed, Cochrane Library, and Google Scholar to
identify studies about antioxidant supplement in prevention of
dementia. There are two studies included in our study. We did
not do a meta-analysis because of without available data and we
made a descriptive analysis.
One study shows that the use of vitamin E combined with
vitamin C supplements can reduce Alzheimer disease prevalence
[adjusted odds ratio (0.22); 95% confidence interval (CI) (0.05-
0.60)] as well as incidence [(adjusted hazard ratio (0.36); 95%
CI (0.09-0.99)]. In addition, this study indicates that the use of
vitamin E or vitamin C supplements alone, with multivitamins
alone, or with vitamin B-complex supplements cannot lower the
risk of Alzheimer disease [1,2].
Another study shows that dementia incidence is 4.4% (325 of 7338
men) but there are no differences among vitamin E, selenium,
vitamin E combined with selenium, and placebo. Additionally,
a Cox model shows that hazard ratios for incident dementia is
0.88 (95% CI, 0.64-1.20) for vitamin E, 0.83 (95% CI, 0.60-1.13) for
selenium, and 1.00 (95% CI, 0.75-1.35) for vitamin E combined
with selenium compared with placebo. This study indicates that
vitamin E and selenium cannot prevent dementia .
In summary, antioxidant supplement cannot prevent dementia.
However, vitamin E combined with vitamin C supplements may
prevent dementia. Perhaps vitamin E combined with vitamin C
produces a different pharmacological effect than antioxidant.
To our knowledge, our study is the first systematic review which
determine whether antioxidant supplement prevents dementia
or not. Although our study is without strong evidence to confirm
that antioxidant supplement cannot prevent dementia, our
systematic review can provide clinicians or patients with some
important information and indicate the direction for later
research. Elderly people may eat both vitamin E and vitamin C
at the same time to prevent dementia in daily life rather than
eat one of them alone. Further study is required to confirm
whether antioxidant supplement can prevent dementia or not. In
addition, further study should explore the mechanism of vitamin
E combined with vitamin C in prevention of dementia.
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