Abnormal cell behavior including uncontrolled proliferation and migration are evidenced in cancers which arise from multiple gene mutations mainly in somatic cells. Many changes can promote abnormal cell behaviors this review is mainly focusing on cytoskeletal based changes in relation to cancer. Cytoskeletal filaments including microtubules and microfilaments are highly dynamic structures mainly involved in cell movements and proliferation, whereas intermediate filaments are relatively permanent structures, which connect the cell to extra cellular matrix, provide a cellular network and help withstand mechanical stress.
Francis SL and Antonipillai J
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