Abstract

Biochemical Changes in Haematological and Liver Function Parameters in Intoxicated Male Albino Rats Treated with Hymenocardia acida Leaves Ethanolic Extract

In the current study, the biochemical changes in haematological and liver function parameters in Intoxicated Male Albino Rats treated with Hymenocardia acida leaves ethanolic extract on AlCl3-toxicity was investigated. Twenty albino rats assigned to four groups of five each were used. Exactly 100 mg/kg bw of the plant extract was administered to groups 3 and 4 for the experimental period of seven days. At the end of the experimental period, animals were sacrificed and blood collected by cardiac puncture. Biochemical, haematological parameters and Thiobarbituric acid reactive substances (TBARS) were determined. The levels of all serum biochemical parameters measured (alanine transaminase (ALT), apartatate transaminase (AST), alkaline phosphatase (ALP), Glucose, Potassium and total Biliribin) in the aluminium chloride (AlCl3)-induced (negative control) increased significantly (p<0.05) when compared with the normal control, while the ethanolic leaves extract non-significantly (p>0.05) decreased some of these parameters. Furthermore, the leaves extract showed a slight moderation effect on selected haematological parameters. However, comparative effect of the leaves extract on the normal control and on the negative control show that the leave could possibly be toxic. This result show that the ethanolic extract of Hymenocardia acida leaves may possess mild ameliorative effect against aluminium chloride-induced toxicity and may also be toxic in male albino rats.


Author(s):

Ojochenemi E. Yakubu



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